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Both the magnitude and the extent of brain activation during memory-activation tasks in regions affected by Alzheimer's disease, including the left hippocampal, parietal, and prefrontal regions, were greater among the carriers of the APOE E4 allele than among the carriers of the APOE E3 allele. During periods of recall, the carriers of the APOE E4 allele had a greater average increase in signal intensity in the hippocampal region (1.03 percent vs. 0.62 percent, P<0.001) and a greater mean (+/= SD) number of activated regions throughout the brain (15.9 +/= 6.2 vs. 9.4 +/= 5.5, P=0.005) than did carriers of the APOE E3 allele. Longitudinal assessment after two years indicated that the degree of base-line brain activation correlated with degree of decline in memory. Patterns of brain activation during tasks requiring memory differ depending on the genetic risk of Alzheimer's disease and may predict a subsequent decline in memory. |
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Alzheimer's disease
Alzheimer's disease,preclinical
apolipoprotein E
memory
memory,evaluation of
MRI
MRI,abnormal
MRI,functional
preclinical
risk factors
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